منابع مشابه
Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms.
The molecular biology of follicular cell growth in thyroid nodules is still poorly understood. Because gain-of-function (activating) mutations of the thyroid-stimulating hormone receptor (TShR) and/or Gs alpha genes may confer TSh-independent growth advantage to neoplastic thyroid cells, we searched for somatic mutations of these genes in a series of hyperfunctioning and nonfunctioning follicul...
متن کاملPANCREATIC NEUROENDOCRINE NEOPLASMS (pNENs)
Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare lesions that have been increasing in incidence over the past few decades largely because of the diagnosis of pancreatic incidentalomas on cross-sectional imaging. Most of these tumors are nonfunctioning presenting with symptoms secondary to mass effect, metastatic disease or as incidental findings. Diagnostic workup aims to assess ...
متن کاملPancreatic carcinoids (serotonin-producing pancreatic neuroendocrine neoplasms)
INTRODUCTION Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare tumors representing 1% to 2% of all pancreatic neoplasms. These tumors can secrete a variety of biologically active substances giving rise to distinct clinical symptoms or can be clinically nonfunctioning. Apart from insulinomas and gastrinomas, which constitute the majority of functioning pNENs, some tumors may secret...
متن کاملEvolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005.
OBJECTIVE To assess changing patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms (PNENs). DESIGN Retrospective review from May 21, 1977, through September 16, 2005. SETTING Massachusetts General Hospital, a tertiary care center. PATIENTS We evaluated 168 patients (51% male; mean age, 56 years) who underwent surgery for histologically confirmed PNENs. MAIN OUTCO...
متن کاملNonfunctioning Juxtaglomerular Cell Tumor
The juxtaglomerular cell tumor (JGCT) is a rare renal tumor characterized by excessive renin secretion causing intractable hypertension and hypokalemia. However, asymptomatic nonfunctioning JGCT is extremely rare. Here, we report a case of nonfunctioning JGCT in a 31-year-old woman. The patient presented with a left renal tumor without hypertension or hypokalemia. Under a clinical diagnosis of ...
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ژورنال
عنوان ژورنال: Current Opinion in Endocrine and Metabolic Research
سال: 2021
ISSN: 2451-9650
DOI: 10.1016/j.coemr.2021.04.007